Cholesterol-modulating effects of Korean red ginseng (KRG) targeting PCSK9 in hyperlipidemia.

ABSTRACT: Hyperlipidemia represents a major global health concern, closely linked to cardiovascular disease (CVD) and metabolic syndrome. Effective regulation of blood lipid and cholesterol (CHO) is essential for preventing and managing this condition. Korean red ginseng (KRG), a traditional medicinal plant, exhibits diverse pharmacological properties, including antihyperlipidemic, immune-enhancing, anti-fatigue, and antistress effects. While previous studies suggest that KRG reduces lipid levels and may lower the risk of hyperlipidemia and CVD, its precise molecular mechanisms remain unclear. In this study, proteomic analysis revealed that KRG modulates proprotein convertase subtilisin/kexin type 9 (PCSK9) in the blood of KRG-administered rats. In hyperlipidemic animal models induced by Triton WR-1

SUBMITTER: Lee CH 

PROVIDER: S-EPMC12368075 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature