Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.

ABSTRACT: Currently, most studies of depression are limited to a single disease endpoint. This study aimed to conduct an umbrella review to comprehensively assess the association between depression and health outcomes. Until December 17, 2024, we conducted a systematic search of systematic reviews and meta-analyses in PubMed, Embase, and Web of Science. We reanalyzed the summary effects and 95% confidence intervals for each study using random models. We assessed the methodological quality and evidence quality of the research with A Measurement Tool to Assess Systematic Reviews 2 and Grade of Recommendations, Assessment, Development and Evaluation, classifying studies into four categories based on evidence classification criteria. We selected a total of 72 articles from 27,150 resulting in 114 meta-a

SUBMITTER: Chen X 

PROVIDER: S-EPMC12368087 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature