PIBF1 expression and survival outcome in TNBC and Non-TNBC breast cancer patients with lymph node metastasis who undertaken chemotherapy.

ABSTRACT: Progesterone-induced blocking factor 1 (PIBF1) is linked to pregnancy-induced immunity and tumor evasion of maternal immunity. PIBF1 is overexpressed in several cancers, including breast, cervical, and lymphoma. However, limited research is available on the role of PIBF1 in breast cancer and its clinical outcomes. Therefore, we investigated the relationship between PIBF1 expression, prognosis, and its impact on chemotherapy response. Samples from 231 patients with high-risk triple-negative breast cancer (TNBC) who underwent surgery between 2008 and 2013 with lymph node metastasis and underwent taxane-based adjuvant chemotherapy were collected. Additionally, 238 non-TNBC patients matched to TNBC patients were selected. Immunohistochemical detection of the PIBF1 protein in tissues was conduc

SUBMITTER: Shin E 

PROVIDER: S-EPMC12368091 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature