Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae.

ABSTRACT: The inflammatory foreign body response (FBR) following cochlear implantation (CI) can negatively impact CI outcomes, including increased electrode impedances. This study aims to investigate the long-term efficacy of dexamethasone-eluting cochlear implant and locally delivered dexamethasone, a potent anti-inflammatory glucocorticoid, on the intracochlear FBR and electrical impedance post-implantation in a murine model. Preliminary impedance data in humans are also provided as a complement to the murine data to illustrate generalizability and reinforce implications related to clinical application. The left ears of CX3CR1^+/GFP Thy1^+/YFP (macrophage-neuron dual reporter) mice were implanted with dexamethasone-eluting cochlear implants (Dex-CI) or standard implant (Standar

SUBMITTER: Rahman MT 

PROVIDER: S-EPMC12368128 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature