Determination of miRNA in tear extracellular vesicles significantly associated with treatment-requiring retinopathy of prematurity: a pilot study.

ABSTRACT: Retinopathy of prematurity (ROP) develops in some premature infants and may be characterized by permanent severe retinal damage necessitating early detection and prompt treatment. The purpose of this study was to investigate whether specific miRNAs in tear extracellular vesicles (EVs) are associated with the development of ROP requiring treatment. Tear samples were collected from 47 infants, including 33 with ROP and 14 without ROP; of the ROP group, 18 infants required treatment. The miRNAs expressed in EVs were profiled by real-time PCR array. An exploratory analysis of differential miRNA expression using tear EV samples from 35 infants was performed. Network analysis conducted for the miRNAs for ROP requiring treatment revealed critical networks of miRNAs linked to IGF1R and VEGF. A mac

SUBMITTER: Kanei S 

PROVIDER: S-EPMC12368132 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature