Micro-computed tomography to visualize preserved vascular architecture in decellularized human vaginal tissue: explorative study.

ABSTRACT: When a vagina is dysfunctional or absent, a neovagina is typically created using an intestinal or dermal graft. This causes complications and complaints from different inherent tissue properties. We recently developed an organ-specific matrix from healthy, human vaginal wall tissue by decellularization, and demonstrated native-like matrix protein composition and mechanical properties. However, the preservation of its vascular structures is unknown, but plays a crucial role for recellularization, tissue survival and graft integration during clinical applicability. Therefore, in this explorative study the vascular architecture of human native and decellularized vagina tissue were assessed and compared. Micro-computed tomography (micro-CT) was used to analyze and quantify the three-dimensiona

SUBMITTER: Sueters J 

PROVIDER: S-EPMC12368158 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature