Drug screening in pharmaceutical and forensic applications using extractive-liquid sampling electron ionization-mass spectrometry (E-LEI-MS).

ABSTRACT: In a wide range of fields, including the pharmaceutical industry and forensic science, obtaining real-time results is paramount. Hence, new analytical techniques are being developed to be both simple and fast, providing results in a few minutes. Extractive-liquid Sampling Electron Ionization-Mass Spectrometry (E-LEI-MS) is proposed as a novel analytical approach that combines an ambient sampling with the high identification power of electron ionization, providing the results in less than five minutes. E-LEI-MS was employed to analyze 20 industrial drugs belonging to different therapeutic classes and pharmaceutical forms, to evaluate its ability to detect active pharmaceutical ingredients and excipients. All samples were analyzed without any pre-treatment. Additionally, the system was coupl

SUBMITTER: Nevola G 

PROVIDER: S-EPMC12368195 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature