Parkinson's disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial.

ABSTRACT: Parkinson's disease (PD) is characterized by motor fluctuations, with alternating periods of good ("ON") and poor ("OFF") motor function. Monitoring these fluctuations is crucial for optimizing treatment, yet traditional methods rely on subjective patient reports. This multicenter, single-blind, cluster-randomized trial evaluated the effectiveness of three monitoring approaches in real-world clinical practice. Neurologists from 35 centers were randomized into three groups: one using clinical visit data alone, another incorporating Hauser diary entries, and a third integrating Parkinson's Holter (STAT-ON®) reports. A total of 156 patients were recruited. Changes in 'OFF time' from baseline to 26 weeks were minimal and non-significant across groups. Secondary outcomes, including 'ON time,' d

SUBMITTER: Rodriguez-Molinero A 

PROVIDER: S-EPMC12368221 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature