MicroRNA-576-5p ameliorates dexamethasone-induced BMSC injury by suppressing ANXA2.

ABSTRACT: Dysfunction of Bone Marrow Derived Mesenchymal Stem Cells (BMSCs) induced by glucocorticoids has been identified as a key pathological mechanism of steroid-induced osteonecrosis of the femoral head (SONFH). Consequently, restoring the function of BMSCs is a vital strategy for treating SONFH. This study aimed to investigate the role of microRNA-576-5p (miR-576-5p) and Annexin A2 (ANXA2) in SONFH and dexamethasone (DEX) cultured BMSCs, expecting to seek new therapeutic strategies for SONFH. RNA and protein samples were extracted from the bone tissue of femoral heads and DEX treated BMSCs to verify the potential relationship among miR-576-5p, ANXA2 and SONFH. Then, the interaction between miR-576-5p and ANXA2 mRNA was investigated through dual luciferase reporter assays. Finally, BMSC prolife

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12368243 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature