Plasma proteomic signatures of dual cognitive and mobility decline in older adults.

ABSTRACT:

Background

The simultaneous memory and gait decline is linked to greater dementia risk than memory decline alone. We aim to identify dual decline-related protein changes that may offer valuable insights into biological processes.

Methods

We compared longitudinal changes in 7268 plasma proteomic markers in older adults experiencing dual decline, memory decline, and gait decline from no decline (reference) using linear mixed-effects regression and related to brain MRI and blood biomarkers.

Findings

There were no baseline group differences in proteins. Longitudinally, only dual decline showed significant changes in 75 proteins, with PGP9.5 showing the most alteration (p-FDR < 0.05), implicated in synaptic function, proteostasis, and regulation of amyloid precursor protei

SUBMITTER: Tian Q 

PROVIDER: S-EPMC12368291 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature