Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition.

ABSTRACT:

Background

Maternal nutritional status and dietary profile during pregnancy and lactation have short- and long-term impacts on offspring health. However, there is an incomplete understanding of the mechanisms behind these health effects. This study aims to assess the effect of maternal diet on the health of offspring by examining to unravel the impact of maternal diet on offspring health outcomes and evaluate the link between maternal nutrition, human milk immune components and neonatal colonisation as potential mechanisms that mediate the influence of maternal diet in the incidence of infant infections.

Methods

To assess this objective, we used two complementary approaches by which a clinical observational study based on the MAMI birth cohort guided a preclinical interventi

SUBMITTER: Rio-Aige K 

PROVIDER: S-EPMC12368293 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature