SUDEP risk is influenced by longevity genomics: a polygenic risk score study.

ABSTRACT:

Background

Sudden Unexpected Death in Epilepsy (SUDEP) is a rare and tragic outcome in epilepsy, identified by those with the condition as their most serious concern. Although several clinical factors are associated with elevated SUDEP risk, mechanisms underlying SUDEP are poorly understood, making individual risk prediction challenging, especially early in the disease course. We hypothesised that common genetic variation contributes to SUDEP risk.

Methods

Genetic data from people who had succumbed to SUDEP was compared to data from people with epilepsy who had not succumbed to SUDEP and from healthy controls. Polygenic risk scores (PRSs) for longevity, intelligence and epilepsy were compared across cohorts. Reactome pathways and gene ontology terms implicated by the contrib

SUBMITTER: Martins H 

PROVIDER: S-EPMC12368338 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature