<i>Mesua ferrea</i> L. extract Attenuates Angiogenesis Through HIF-1α and WNT Mediated Blockage of VEGF/Angiopoietin Axis.

ABSTRACT:

Objectives

The current study investigated angiogenesis-arresting attributes of Mesua ferrea oleo-gum resin extract and its underlying molecular mechanisms.

Methods

Series of in vitro, ex vivo and in vivo models were used to assess anti-angiogenic properties.

Results

MTT cell viability experiments showed that oleo-gum resin extract induced moderate cytotoxicity towards EA.hy926 cells (IC₅₀ = 42 µg/mL). Extract-treated cells showed significant reduction in invasion, migration, and tube formation potential. At the protein level, down-regulation in expression of angiopoietin-1 and -2, Tie-2, MMP-1 and -9, VEGF-A, and VEGFR2 pro-angiogenic proteins was observed in extract-treated EA.hy926 cells. Signalling array d

SUBMITTER: Zhang F 

PROVIDER: S-EPMC12368410 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature