3D Multi-Tissue microphysiological system for Anti-Cancer and cardiotoxicity drug screening with automated image analysis.

ABSTRACT: In vitro 3D tissue models within microfluidic-based microphysiological systems (MPS) provide controlled and reproducible platforms for quantification of isolated cellular processes in response to biochemical or biophysical stimulus. This study demonstrates the development of a 3D MPS with a dual-chamber, closed-capillary circuit microfluidic culture platform to study chemotherapy drug efficacy in vitro for aggressive malignancies such as breast cancer and glioblastoma. This novel microfluidic system was used to model HER2 + breast cancer (BCTM-SKBR3) co-cultured with cardiac (CTM-AC16) tissue for proof-of-concept chemotherapy-induced cardiotoxicity studies. To further demonstrate the versatility of this system, a glioblastoma tissue model with chemotherapy efficacy studies was included. Ad

SUBMITTER: Borrego EA 

PROVIDER: S-EPMC12368580 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature