Pharmacokinetic Profile and Evaluation of Acute and Subchronic Oral Toxicity of Shikimic Acid in Mice.

ABSTRACT: Shikimic acid, a widely known hydroaromatic compound abundantly found in (commonly known as Chinese star anise), serves as a key intermediate in the synthesis of neuraminidase inhibitors such as oseltamivir. However, its pharmacokinetic (PK) properties and long-term safety profile remain inadequately characterized. This study systematically evaluated its PK behavior following both oral and intravenous administrations, along with its acute toxicity and 28-day subchronic oral toxicity in mice. PK analysis for shikimic acid demonstrated linear and dose-proportional behavior within the intravenous dose range of 4-16 mg/kg. Shikimic acid was rapidly eliminated from plasma, with a short terminal half-life (T1/2) of 0.76-0.85 h. Despite rapid absorption (Tmax, 0.95-1.25 h) following oral administ

SUBMITTER: Liang LY 

PROVIDER: S-EPMC12368620 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature