Targeted-Produced Dirhamnolipids from Induce Antinociception in Mice.

ABSTRACT: Rhamnolipids are highly effective surface-active glycolipid biosurfactants with enormous market potential. Composed of β-d-(β-d-hydroxyalkanoyloxy)-alkanoic acids attached to mono- or dirhamnose moieties, these green amphiphilic molecules exhibit remarkable biomedical prospects, with the double rhamnose congeners being the most effective ones. Although reports on dirhamnolipid antimicrobial activities and wound healing properties are quite abundant, the antinociceptive effect on inflammatory pain has never been tested before. Here we report a targeted-producing dirhamnolipid process, which reaches 95.1% of dirhamnolipid abundance, followed by a single-step purification procedure through a homemade silica cartridge, achieving highly pure glycolipid (99.0% rhamnolipids and 97.5% dirhamnolipi

SUBMITTER: Wessel KBB 

PROVIDER: S-EPMC12368654 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature