Cys-Ala-Gly Peptides and Amphiphilic mPEG-PLGA Polymer Modified ZE21B Magnesium Alloy for Enhanced Anticorrosion and Pro-Endothelialization Potential.

ABSTRACT: Magnesium alloy stents (MASs) provide significant therapeutic benefits for the treatment of cardiovascular disease. Unlike conventional permanent stents, MASs gradually degrade after fulfilling their mechanical support function, thereby reducing the risk of long-term complications. However, the clinical application of MAS is hindered by two primary challenges: excessively rapid degradation in physiological environments and inadequate biocompatibility resulting from the alloy's corrosion behavior. Herein, we developed a multifunctional composite coating on Mg-Zn-Y-Nd (ZE21B) alloy that incorporated a MgF2 layer, amphiphilic methoxy-terminated poly-(ethylene glycol)-b-poly-(lactide-co-glycolide) (mPEG-PLGA) polymer, and bioactive CAG peptides to enhance its corrosion resistance, hemocompatib

SUBMITTER: Jia M 

PROVIDER: S-EPMC12368683 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature