Hepatoprotective Potential of Green Synthesized Nanoparticles from Peel Extract against HFS Diet-Induced NASH in Mice, Integrated with Chemical Profiling and Molecular Modeling.

ABSTRACT: is known for its wide variety of secondary metabolites, including essential oil, alkaloids, flavonoids, and phenolic acids, which are considered the reason for its diverse potential medical uses. Herein, extract was prepared using different formulas of metal oxide nanoparticles as ZnO NPs and MgO NPs with 22.5 ± 1.3 and 18.3 ± 1.5 nm average particle sizes, respectively. The protective effects of extract and its two nano formulas against NASH induced by a high-fat, high-sucrose (HFS) diet in mice were evaluated. The NASH mice showed hepatic steatosis, inflammation, reduced liver function, increased body, liver, and fat weights, elevated hepatic index, and disrupted serum lipid profiles. Additionally, the mice displayed heightened hepatic oxidative stress and increased expression of inflamm

SUBMITTER: Elhady SS 

PROVIDER: S-EPMC12368685 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature