Novel Pyrone-Based Biofilm Inhibitors against Azole-Resistant <i>Candida albicans</i>.

ABSTRACT: Candida albicans is an opportunistic fungus that is pathogenic in immunocompromised patients with life-threatening diseases such as HIV and cancer. C. albicans is the most common fungal species isolated from biofilms formed on implanted medical devices or on human tissue. Biofilm development of C. albicans is mainly driven by a transition from yeast to hyphal form involving core proteins such as HWP and ALS. We designed and synthesized novel α-pyrone-based analogues to investigate their potential in inhibiting biofilm formation and hyphal development of C. albicans . Among the synthesized compounds, three compounds (6f, 6j, and 6n) significantly inhibited C. albicans biofilm formation and reduced cell aggregation and hyphal formation

SUBMITTER: Yang JE 

PROVIDER: S-EPMC12368727 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature