Preparation, Effect, and Mechanism Exploration of Hyaluronic Acid Microneedle Patch with Rapamycin Nanocrystals.

ABSTRACT: Transplant vein restenosis is the main complication affecting the long-term graft patency after coronary artery bypass grafting, mainly caused by VSMC proliferation and migration (initiating factors), leading to intimal hyperplasia and restenosis. Transplant vein restenosis has seriously affected the surgical efficacy of CABG, and the degree of transplant vein restenosis determines the patient's survival time. Therefore, a solution to this problem is urgent. Rapamycin is a cell cycle drug that can inhibit VSMC proliferation and migration but its systemic toxicity is high. In recent years, microneedle drug delivery systems have become a research hotspot with broad clinical application prospects. These systems are capable of achieving sustained, safe, and painless local drug release. In card

SUBMITTER: Ding X 

PROVIDER: S-EPMC12368729 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature