Multiomics Analysis of the Response to Ritlecitinib in Alopecia Areata Subtypes and Correlation With Efficacy.

ABSTRACT:

Background

Alopecia areata (AA) is an autoimmune disease characterized by hair loss. This study examined changes in molecular signatures in lesional scalp of patients with AA subtypes (patchy-type AA [AAP] or alopecia totalis/alopecia universalis [AT/AU]) in response to treatment with JAK3/TEC family kinase inhibitor ritlecitinib and evaluated correlations between potential biomarker levels/changes and scalp hair regrowth.

Methods

This was a post hoc analysis of a biopsy substudy from a phase 2a trial of ritlecitinib in patients with AA and ≥ 50% scalp hair loss. Transcriptomic expression profiles from scalp samples of patients with AAP or AT/AU were analyzed using microarray. Changes from baseline in transcriptional and serum protein expression were evaluated, as were corre

SUBMITTER: Xi L 

PROVIDER: S-EPMC12368755 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature