Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1.

ABSTRACT: Allergic reactions to foods are primarily driven by allergen-binding immunoglobulin (Ig)E antibodies. IgE-expressing cells can be generated through direct switching from IgM to IgE or a sequential class switching pathway where activated B cells first switch to an intermediary isotype, most frequently IgG1, and then to IgE. It has been proposed that sequential class switch recombination is involved in augmenting the severity of allergic reactions, generating high affinity IgE, differentiation of IgE plasma cells, and in holding the memory of IgE responses. We directly tested these possibilities by comparing the allergic immunity of wild-type and IgG1-deficient (hMT) mice. We found that sequential switching through IgG1 was not required to maintain the binding capacity of IgE nor for its abi

SUBMITTER: Koenig JFE 

PROVIDER: S-EPMC12368767 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature