Per- and polyfluorinated substances (PFAS) promote osteoclastogenesis and bone loss through PPARα activation.

ABSTRACT: Per- and polyfluoroalkyl substances (PFAS) are emerging as significant environmental contaminants affecting bone health, with studies linking their exposure to decreased bone mineral density (BMD), enhanced osteoclastogenesis, and disruptions in the bone marrow microenvironment. While current research highlights the effects on bone and BMD, there is a critical gap in understanding the mechanisms behind these effects. Studies presented here investigate the effects of legacy and alternative PFAS, particularly hexafluoropropylene oxide dimer acid (GenX) and perfluorohexane sulfonic acid (PFHxS), on bone health using in vitro and in vivo models. An environmentally relevant mixture of five PFAS was found to promote osteoclastic differentiation of murine bone marrow macrophages (BMMs) in vitro.

SUBMITTER: Garmo LC 

PROVIDER: S-EPMC12368805 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature