Probiotic Subsp. longum 5^1A Protects Mice from Genotoxic and Metabolic Alterations Induced by Subchronic Exposure to a Low-Dose Pesticide Cocktail.

ABSTRACT: Environmental exposure to low levels of pesticide mixtures through food and domestic settings raises significant public health concerns due to their potential link to metabolic diseases, including obesity, type 2 diabetes, and cancer. As the intestinal microbiota and gastrointestinal tract serve as primary contact points for these contaminants, potentially eliminating residues or suffering direct damage leading to dysbiosis, probiotic interventions have emerged as promising therapeutic strategies for metabolic disorders. This study aimed to evaluate, in mice, the consequences of subchronic exposure to low doses of a mixture of three pesticides: glyphosate (15 mg/kg body weight/day), imidacloprid (5 mg/kg body weight/day), and tebuconazole (4 mg/kg body weight/day). Mice were exposed for 6

SUBMITTER: Maciel d'Auriol Souza M 

PROVIDER: S-EPMC12368810 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature