Targeting Cancer with New Morpholine-Benzimidazole-Oxadiazole Derivatives: Synthesis, Biological Evaluation, and Computational Insights.

ABSTRACT: Cancer remains one of the leading causes of mortality worldwide, characterized by uncontrolled cell proliferation, invasion of surrounding tissues, and metastasis to distant organs. Among various malignancies, colon cancer is particularly aggressive and often associated with poor prognosis in advanced stages. This study presents the design, synthesis, and biological evaluation of a new series of morpholine-benzimidazole-oxadiazole derivatives as potential anticancer agents. The anticancer potential of the synthesized derivatives was assessed through MTT assays against the human colon cancer cell line (HT-29) and normal fibroblast cells (NIH3T3) to evaluate their selectivity. To further investigate their mechanism of action, VEGFR-2 enzyme inhibition assays were conducted, as VEGFR-2 plays

SUBMITTER: Halimi Syla G 

PROVIDER: S-EPMC12368815 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature