Pathogen Adaptation of HLA Alleles and Its Correlation with Autoimmune Diseases in the Han Chinese.

ABSTRACT: Human leukocyte antigen (HLA) genes play a crucial role in the adaptation of human populations to the dynamic pathogenic environment. Despite their significance, investigating the pathogen-driven evolution of HLAs and its implications for autoimmune diseases presents considerable challenges. Here, we genotyped over 20 HLA genes at 3-field resolution in 8278 individuals from diverse ethnic backgrounds, including 4013 unrelated Han Chinese individuals. We focused on the adaptation of HLAs in the Han Chinese population by analyzing their binding affinity for various pathogens, and explored the potential correlations between pathogen adaptation and autoimmune diseases. Our findings reveal that specific HLA alleles like HLA-DRB1*07:01 and HLA-DQB1*06:01 confer strong pathogen adaptability at th

SUBMITTER: Liu 刘帅 S 

PROVIDER: S-EPMC12368854 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature