Nephroprotective Effects of Fraxinus Hookeri Wenz. Against Renal Toxicity and DNA Oxidative Damages Induced by CCl₄ in Rats.

ABSTRACT: Recognizing the therapeutic value of the Genus Fraxinus worldwide, this study evaluates the antioxidant potential of Fraxinus hookeri Wenz. (F. hookeri) against CCl₄-induced nephrotoxicity in rats. Forty-eight rats are randomly allocated into eight groups (six rats each). Antioxidant enzymes, genotoxicity, urine and serum markers, and tissue histopathology are assessed to determine their nephroprotective effects. The Control group remains untreated, while the DMSO group receives vehicle olive oil intraperitoneally and DMSO orally (3 ml/kg). All other groups, except Control and DMSO, are given CCl₄ (3 ml/kg, i.p., in 30% olive oil) twice weekly for 4 weeks. The CCl₄ group receives only CCl₄. The Rutin group receives reference drug Rutin orally (50

SUBMITTER: Sarwar R 

PROVIDER: S-EPMC12368880 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature