Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.

ABSTRACT:

Background

Multiple environmental and genetic factors play a role in the pathogenesis of atopic eczema (AE). We aimed to investigate gene-environment interactions (G × E) to improve understanding of the pathophysiology.

Methods

We analysed data from 16 European studies to test for interaction between the 24 most significant AE-associated loci identified from genome-wide association studies and 18 early-life environmental factors. We tested for replication using a further 10 studies and in vitro modeling to independently assess findings.

Results

The discovery analysis (including 25,339 individuals) showed suggestive evidence for interaction (p < 0.05) between seven environmental factors (antibiotic use, cat ownership, dog ownership, breastfeeding, elder sibling, smokin

SUBMITTER: Standl M 

PROVIDER: S-EPMC12368900 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature