Biosynthesis of CDP-α-d-fucofuranose and CDP-β-l-6-deoxy-altrofuranose for the Capsular Polysaccharides of <i>Campylobacter jejuni</i>.

ABSTRACT: Campylobacter jejuni is a Gram-negative human pathogen and is the most common cause of gastroenteritis in the United States and Europe. C. jejuni expresses a capsular polysaccharide (CPS) that enables the evasion of the host immune response and adherence to host epithelial cells. The various subspecies (serotypes) of C. jejuni are distinguished by their unique CPS repeating units. The repeating trisaccharide in the HS:41 serotype was previously found to contain l-arabinofuranose, 6-deoxy-d-altro-heptofuranose, and a third sugar, which is either d-fucofuranose or 6-deoxy-l-altrofuranose. Genome neighborhood and sequence similarity networks were employed to identify five candidate genes for the biosynthesis of d-fucofuranose and 6-deoxy-l-altrofuranose. Here, it w

SUBMITTER: Errickson Simons M 

PROVIDER: S-EPMC12369002 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature