Genetic surveillance of Plasmodium-Anopheles compatibility markers during Anopheles stephensi associated malaria outbreak.

ABSTRACT:

Background

Despite a previous decline in malaria in Ethiopia, an outbreak in Dire Dawa in 2022 implicated the invasive vector Anopheles stephensi as responsible. The efficient transmission of Plasmodium by invasive An. stephensi raises questions about the molecular basis of compatibility between parasite and vector, and the origin of the Plasmodium being transmitted. The Plasmodium P47 gene is involved in parasite-vector interactions in the mosquito, and along with the corresponding mosquito P47 receptor (P47Rec), can be critical in the establishment of Plasmodium infections in anophelines.

Methods

Herein, we analyzed P47 and P47Rec sequences to determine the origin of Plasmodium detected in An. stephensi during the outbreak and evaluate markers of compatibility. This was co

SUBMITTER: Waymire E 

PROVIDER: S-EPMC12369046 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature