A SORT1/EGFR molecular interplay as a prognostic biomarker in glioblastoma vasculogenic mimicry: implications in the transcriptional regulation of cancer stemness and drug resistance.

ABSTRACT: The epidermal growth factor receptor (EGFR) plays a significant role in vasculogenic mimicry (VM), a process by which aggressive cancer cells within hypoxic solid tumors form blood vessel-like structures independent of endothelial cells. Mostly attributed to cancer stem cells (CSC), VM is strongly associated with chemoresistance and poor prognosis in glioblastomas (GBMs). The trafficking of EGFR from the plasma membrane is in part regulated by Sortilin (SORT1), a type I membrane glycoprotein with receptor sorting functions. Notably, EGFR and SORT1 have been reported to also localize within exosomes. This study questions whether the EGFR/SORT1 interplay impacts in vitro VM in human GBM-derived cell models. In silico analysis was used to compare GBM to healthy brain tissue transcripts levels

SUBMITTER: Roy ME 

PROVIDER: S-EPMC12369051 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature