First report of Leishmania RNA virus 2 and its high genetic diversity in cutaneous leishmaniasis cases from Ilam Province, Iran.

ABSTRACT:

Introduction

Cutaneous Leishmaniasis (CL) is a vector-borne disease caused by a protozoan parasite and considered a public health challenge in many countries, including Iran. Recent research has focused on the role of Leishmania RNA virus (LRV) in the pathogenesis of cutaneous and mucosal forms of leishmaniasis. This study assessed the presence of LRV2 and its genotype diversity among isolates in Ilam province, western Iran, an old focus of Zoonotic CL.

Material and method

Thirty-two lesion specimens were collected from CL patients and subjected to PCR analysis using species-specific primers for Leishmania identification and detection of LRV2. The amplified products were sequenced, and phylogenetic analysis was performed.

Result

All samples were identified as L. major

SUBMITTER: Saberi R 

PROVIDER: S-EPMC12369053 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature