Metformin for the treatment of breast cancer: a scoping review of randomized clinical trials.

ABSTRACT: Metformin has been the focus of substantial interest in the field of oncology. Although breast cancer is the type of cancer where metformin was most extensively studied through randomized clinical trials (RCTs), none of the previous reviews in this field provided a comprehensive overview of the landscape of RCTs taking into account the phenotype of breast cancer, its staging, and treatment modalities. This scoping review sought to comprehensively map the literature of RCTs focusing on the use of metformin in the treatment of breast cancer and followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Extension for Scoping Reviews guidelines. The eligibility criteria encompassed all RCTs involving metformin for adult patients with breast cancer, with no constrai

SUBMITTER: Araujo CFM 

PROVIDER: S-EPMC12369099 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature