Muscle strength and mass as predictors of pancreatic cancer: insights from the UK biobank.

ABSTRACT: While sarcopenia is associated with adverse pancreatic cancer (PC) outcomes, prospective evidence linking muscle health to PC risk remains limited. This study aimed to prospectively investigate the associations of grip strength and muscle mass with incident PC risk in the UK Biobank cohort. Among 363,693 UK Biobank participants, grip strength (kg) and bioelectrical impedance analysis (BIA)-derived muscle mass (weight-normalized) were measured. Cox proportional hazards models, adjusted for age, sex, lifestyle factors, and metabolic syndrome components, assessed PC risk over a median 13.7-year follow-up. Higher muscle mass (HR = 0.86, 95% Confidential Interval [CI]:0.78-0.95) and grip strength (HR = 0.90, 95% CI:0.83-0.98) demonstrated linear inverse associations with PC risk showing sex-spe

SUBMITTER: Liu X 

PROVIDER: S-EPMC12369202 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature