Early use of albumin may increase the risk of sepsis-associated acute kidney injury in sepsis patients: a target trial emulation.

ABSTRACT: Most sepsis patients develop sepsis-associated acute kidney injury (SA-AKI), which poses a significant threat to survival and lacks specific treatment. To date, there are no published randomized controlled trials that have established a link between albumin use and SA-AKI development in sepsis. Therefore, it is unclear whether albumin use may influence the risk of SA-AKI. The present study employed a target trial emulation using observational data to track adult sepsis patients initially admitted to the intensive care unit at Beth Israel Deaconess Medical Center, Boston, Massachusetts, for a period of 7 d from 2008 to 2022. Immortal time bias was controlled using the clone-censor-weight (CCW) method, along with a new-user design to address current user bias. The exposure variable was the e

SUBMITTER: Li XY 

PROVIDER: S-EPMC12369241 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature