Estimated glucose disposal rate and risk of cardiovascular events in type 1 diabetes: a systematic review and meta-analysis.

ABSTRACT: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in individuals with type 1 diabetes mellitus (T1DM), with insulin resistance (IR) increasingly recognized as a key contributor. The estimated glucose disposal rate (eGDR), a surrogate marker of insulin sensitivity, has been proposed as a predictor of adverse cardiovascular outcomes in T1DM. This systematic review and meta-analysis aimed to assess the association between eGDR and adverse cardiovascular outcomes. A systematic search of PubMed, Embase, Scopus, and Cochrane Library was conducted through March 6, 2025, to identify studies reporting multivariable-adjusted risk estimates linking eGDR with cardiovascular outcomes in individuals with T1DM. Pooled hazard ratios (HRs) were estimated using random-effects mode

SUBMITTER: Dastjerdi P 

PROVIDER: S-EPMC12369242 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature