Epidermal differentiation complex genetic variation in atopic dermatitis and peanut allergy.

ABSTRACT:

Background

Deleterious variation in the epidermal differentiation complex (EDC) on chromosome 1 is a well-known genetic determinant of atopic dermatitis (AD) and has been associated with risk of peanut allergy (PA) in population-based studies.

Objective

Our aim was to determine the effect of genetic variation in the EDC on AD trajectory and risk of PA in early life.

Methods

Genome sequencing was used to measure genetic variation in the EDC in the Learning Early about Peanut Allergy (LEAP) study participants. Association tests were done to identify gene- and variant-level predicted deleterious variation associated with AD severity by using the Scoring Atopic Dermatitis (SCORAD) tool (n = 559) at baseline and each follow-up visit, as well as PA and food allergy in peanu

SUBMITTER: Huffaker MF 

PROVIDER: S-EPMC12369244 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature