FBXO42 promotes hepatocellular carcinoma progression via mediating p57Kip2 ubiquitination and degradation.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC), one of the most common malignancies, accounts for about 80% of all primary liver cancers. FBXO42 belongs to the F-box protein family and functions as a key component of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex, which is involved in the process of protein ubiquitination. The studies on the role of FBXO42 in different diseases are inadequate, especially in HCC.

Methods

The expression and the clinical features of FBXO42 in HCC were assessed using the HCCDB, TCGA, and ICGC databases. cBioPortal and SangerBox databases were used to analyze the genetic alterations and mutation profile of FBXO42. TIMER, TISIDB and GEPIA databases were used to examine the correlation of FBXO42 with tumor-infiltrating immune cells, tumor-associat

SUBMITTER: Zhou B 

PROVIDER: S-EPMC12369267 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature