Benchmark dose modeling for epidemiological dose-response assessment using case-control studies.

ABSTRACT: Following a previous article that focused on integrating epidemiological data from prospective cohort studies into toxicological risk assessment, this paper shifts the focus to case-control studies. Specifically, it utilizes the odds ratio (OR) as the main epidemiological measure, aligning it with the benchmark dose (BMD) methodology as the standard dose-response modeling approach to determine chemical toxicity values for regulatory risk assessment. A standardized BMD analysis framework has been established for toxicological data, including input data requirements, dose-response models, definitions of benchmark response, and consideration of model uncertainty. This framework has been enhanced by recent methods capable of handling both cohort and case-control studies using summary data that

SUBMITTER: De Pretis F 

PROVIDER: S-EPMC12369292 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature