State-dependent neural representations of muscle synergies in the spinal cord revealed by optogenetic stimulation.

ABSTRACT: The central nervous system controls movement by combining neuromotor modules, known as muscle synergies. Previous studies suggest that spinal premotor interneurons (PreM-INs) contribute to the encoding of stable muscle synergies for voluntary movement. But descending and sensory inputs also influence motor outputs through the spinal interneuronal network, which may be configured by its inputs to encode different sets of muscle synergies depending on the network state, thereby recruiting different selections of synergies. Here we tested this possibility of state-dependent synergy encoding by examining the muscle synergies represented by the same upstream spinal interneurons under different activity states induced by various optogenetic stimulation patterns. Lumbosacral spinal units and elec

SUBMITTER: He B 

PROVIDER: S-EPMC12369310 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature