Phosphorylation of the cell wall hydrolase MltG in response to cell wall stress modulates resistance toward cephalosporins in <i>Enterococcus faecalis</i>.

ABSTRACT: Enterococcus faecalis is an opportunistic pathogen that colonizes the human gut microbiome. E. faecalis commonly establishes infection subsequent to antibiotic therapy in patients due to intrinsic resistance exhibited by E. faecalis toward cephalosporins and acquired resistance to many clinically used antibiotics. Intrinsic resistance toward cephalosporins in E. faecalis depends on the kinase activity of IreK, a transmembrane serine/threonine PASTA kinase that mediates responses to cell wall stress, including stress caused by cephalosporins, by phosphorylating downstream effector proteins. Our previous phosphoproteomics analysis identified MltG, a transmembrane protein with an extracellular catalytic domain that cleaves nascent peptidoglycan strands, as a putati

SUBMITTER: Knotek AAU 

PROVIDER: S-EPMC12369325 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature