Pyrimidine sufficiency is required for Sae two-component system signaling in <i>Staphylococcus aureus</i>.

ABSTRACT: Nucleotide metabolism in pathogens is essential for their virulence, supporting their growth, survival, and immune evasion during infection. Virulence in Staphylococcus aureus is driven by the production of virulence factors that facilitate nutrient acquisition and promote immune evasion and subversion. One key virulence regulatory system is the Sae two-component system, which upregulates the production of various virulence factors. The sensor histidine kinase SaeS, a member of the intramembrane family of histidine kinases (HKs), lacks a signal-binding domain, leaving the mechanisms by which these HKs sense signals and regulate gene expression unclear. We report that pyrimidine sufficiency is essential for maintaining Sae activity. Disruption of genes involved in pyrimidine biosynth

SUBMITTER: DiMaggio DA 

PROVIDER: S-EPMC12369341 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature