The PDZ domain of EpsC is required for extracellular secretion of VesB by the Type II secretion system in <i>Vibrio cholerae</i>.

ABSTRACT: The Type II Secretion System (T2SS) of the Gram-negative pathogen Vibrio cholerae is considered a virulence factor primarily because it facilitates the secretion of cholera toxin upon arrival of this pathogen in the human intestinal lumen, resulting in the profuse watery diarrhea associated with infection. Results from transposon mutagenesis screens suggest that the V. cholerae eps genes that code for the T2SS are essential. The deletion of these genes impairs the secretion of the T2SS's nearly two dozen protein substrates, leading to the selection of suppressor mutations, extracytoplasmic stress, and poor growth of the mutant bacteria. Here, we explore the role of the C-terminal PDZ domain of the T2SS component EpsC, and why transposon insertions in pdz do not affect

SUBMITTER: Shannon A 

PROVIDER: S-EPMC12369372 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature