Advances in Xanthine Oxidase Inhibition: A Review of Potential Bioactive Synthetic Compounds.

ABSTRACT: Hyperuricemia and gout are conditions that continue to present significant therapeutic challenges, mainly due to limitations of current treatments which may cause adverse effects such as hypersensitivity, hepatotoxicity, and cardiovascular risks. Additionally, the development of new drugs faces obstacles including toxicity, low bioavailability, and potential drug interactions. In this context, the search for new synthetic xanthine oxidase inhibitors is essential to improve treatment efficacy, selectivity, and safety. New molecules can not only prolong the duration of therapeutic effects but also minimize adverse reactions. Moreover, several compounds under investigation exhibit additional pharmacological activities, such as anti-inflammatory, antioxidant, anticholinesterase, and anticancer

SUBMITTER: Antoniolli G 

PROVIDER: S-EPMC12369460 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature