Intravenous lidocaine as an adjuvant to propofol sedation for elderly patients undergoing same-visit bidirectional endoscopy: protocol for a multicenter randomized controlled trial.

ABSTRACT:

Background

Same-visit bidirectional endoscopic procedures under sedation are frequently performed in elderly patients. However, the optimal sedation regimen for elderly patients remains uncertain. This study seeks to evaluate the hypothesis that intravenous lidocaine, when used as an adjunct to propofol sedation, reduces the incidence of sedation-related adverse events during these procedures.

Methods

This multicenter, randomized, double-blind, placebo-controlled trial will enroll 648 elderly patients scheduled for same-visit bidirectional endoscopy under sedation at four hospitals in China. Participants will be randomized in a 1:1 ratio to receive either intravenous lidocaine or normal saline (placebo), stratified by study center (n = 324 per group). All patients wil

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12369516 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature