DNA methylation associations with cognitive function in early-stage hormone receptor-positive breast cancer patients.

ABSTRACT:

Background

Approximately one-third of breast cancer (BC) patients show poorer cognitive function (CF). Using DNA methylation (DNAm) data, here we aimed to identify genes and biological pathways associated with CF in postmenopausal women with early-stage hormone receptor-positive (HR+) BC.

Methods

Epigenome-wide association studies (EWAS) and differentially methylated region analyses were performed for each CF phenotype (seven objective domains and one subjective phenotype) using DNAm data from whole blood samples (n = 109) taken at the time of enrollment.

Results

When adjusting for age, verbal IQ scores, and global DNAm signature, cg10331779 near CTNND2 (p-value = 9.65×10-9) and cg25906741 in MLIP (p-value = 2.01×10-8) were associated with process

SUBMITTER: Liu S 

PROVIDER: S-EPMC12369613 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature