Dominance of DENV-1 and Flavivirus Serological Cross-Reactivity During the 2016 Dengue Outbreak in Vietnam.

ABSTRACT: Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV) pose a major health burden in Vietnam, where overlapping clinical features and serological cross-reactivity complicate accurate diagnosis and outbreak control. This study aimed to investigate circulating DENV serotypes and assess serological cross-reactivity with other flaviviruses during the 2016 dengue outbreak in central Vietnam. Aretrospective study was conducted on 146 hospitalized dengue patients during the 2016 outbreak in Binh Dinh province. Laboratory diagnosis included NS1antigen testing, ELISA (IgM/IgG), and real-time RT-PCR for DENV serotyping. IgM and IgG cross-reactivity with five flaviviruses, including DENV, ZIKV, JEV, West Nile virus (WNV), and tick-borne encephalitis virus (

SUBMITTER: Anh DD 

PROVIDER: S-EPMC12369675 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature