Noradrenaline Modulates Central Amygdala GABA Transmission and Alcohol Drinking in Female Rats.

ABSTRACT:

Background

Alcohol use disorder (AUD) is a chronic relapsing disorder and a leading preventable cause of death worldwide. The central nucleus of the amygdala (CeA) is a hub for stress and AUD. Norepinephrine (NE), also known as noradrenaline, regulates the brain's response to stress and alcohol. We previously reported that α₁-adrenergic receptors drive moderate alcohol intake, while β receptors contribute to excessive drinking associated with dependence in male rats.

Methods

Here, we determined that alcohol dependence and withdrawal alter the CeA noradrenergic system in female rats using ex vivo electrophysiology, in situ hybridization, and site-specific behavioral pharmacology. We also analyzed RNA-sequencing data from postmortem CeA samples obtained from female

SUBMITTER: Anjos-Santos A 

PROVIDER: S-EPMC12369889 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature