Exploring racial differences in second-harmonic-generation-based prognostic indicators of metastasis in breast and colon cancer.

ABSTRACT: Second-harmonic generation (SHG) analysis of collagen internal structure and overall organization in the tumor microenvironment may enhance current metastasis prediction methods, which do not prognosticate with the same accuracy for patients of different races. For these optical tools to be clinically available, a multicenter trial is needed. We investigate if SHG-based prognostic signals vary with patient race, providing insight for designing such a trial. SHG imaging was performed on colon adenocarcinoma (CRC) and invasive ductal carcinoma (IDC) patient samples to derive two prognostic indicators. We assessed the association between these indicators and patient race. SHG images were analyzed as previously described to determine the forward- to backward-SHG scattering ratio (F/B) and fibe

SUBMITTER: Elias TM 

PROVIDER: S-EPMC12369920 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature