SRC Kinase Isoforms Regulate mRNA Splicing during Neural Development.

ABSTRACT: Alternative mRNA splicing generates transcriptomic diversity to direct tissue-specific functions. There is a high level of alternative splicing in the brain during embryonic development, but the master regulators of this process are poorly understood. One key splicing event in neuronal differentiation is the inclusion of a microexon in the SH3 domain of the ubiquitous tyrosine kinase, C-SRC, to yield the constitutively active, neural-specific N1-SRC kinase. We previously demonstrated that specific inhibition of N1-SRC in developing Xenopus embryos inhibits neurogenesis, but the targets and mode of action of N1-SRC were unknown. In the current study, we screened for N1-SRC SH3 domain interactors, surprisingly finding no unique targets compared with the C-SRC SH3 domain, but rather a

SUBMITTER: Pizzey AR 

PROVIDER: S-EPMC12369926 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature